3-(3-甲氧基苯基)-哌啶合成路线 （共 15 条）
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: Et3SiH; boron trifluoride etherate / CH2Cl2 / 4 h / 0 °C 3: Na/Hg; sodium phosphate / methanol / 2 h / 20 °C View Scheme
参考文献
Heterocycles, , vol. 68, # 6 p. 1173 - 1183
反应条件
sodium cyanoborohydride in tetrahydrofuran; methanol
T=20°C; 18 h;
参考文献
Chang, Meng-Yang; Hsu, Ru-Ting; Chen, Hua-Ping; Lin, Pei-Jung
Heterocycles, 2006 , vol. 68, # 6 p. 1173 - 1183
反应条件
hydrogen bromide in water
T=140°C; 4 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/48334 A1, 2004 ;
Location in patent: Page 104-105 ;
WO 2004/048334 A1
反应条件
carbon dioxide in methanol
T=30°C; P=75007.5 Torr; Resolution of racemateInert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BROTHERTON-PLEISS, Christine E.; CHEN, Zhi; ERICKSON, Shawn David; KIM, Kyungjin; LI, Hongju; LOVEY, Allen John; QIAN, Yimin; SO, Sung-Sau; WOVKULICH, Peter Michael; YI, Lin
Patent: WO2014/60341 A1, 2014 ;
Location in patent: Paragraph 0085 ;
参考文献
Grayson, Neile A.; Bowen, Wayne D.; Rice, Kenner C.
Heterocycles, 1992 , vol. 34, # 12 p. 2281 - 2292
