3-(3,4-二乙氧基苯基)丙酸合成路线 （共 7 条）
反应条件
1: ammonia / Erhitzen des erhaltenen Ammonium-Salzes im Ammoniak-Strom auf 200grad 2: sodium hypochlorite View Scheme
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1934 , vol. 272, p. 60,68
反应条件
1: With sulfuric acid in ethanol
T=20°C; 3 h; Heating / reflux;
2: With potassium carbonate; ethyl iodide in DMF (N,N-dimethyl-formamide)
T=50°C; 5 h;
3: With sodium hydroxide in tetrahydrofuran
1 h; Heating / reflux;
参考文献
Eisai Co., Ltd.
Patent: EP1468684 A1, 2004 ;
Location in patent: Page/Page column 16 ;
反应条件
1: With lithium hydroxide; water in methanol; ethanol
T=20°C; 0.5 h;
2: With hydrogenchloride in water
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/132679 A1, 2008 ;
Location in patent: Page/Page column 83 ;
WO 2008/132679 A1
反应条件
palladium; acetic acid
Hydrogenation.Behandlung des Reaktionsprodukts mit aethanol. Kalilauge;
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1934 , vol. 272, p. 60,68
反应条件
1: sodium; benzene
2: palladium; acetic acid / Hydrogenation.Behandlung des Reaktionsprodukts mit aethanol. Kalilauge
View Scheme
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1934 , vol. 272, p. 60,68
反应条件
1: ethanolic sodium ethylate / 130 °C
2: sodium; benzene
3: palladium; acetic acid / Hydrogenation.Behandlung des Reaktionsprodukts mit aethanol. Kalilauge
View Scheme
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1934 , vol. 272, p. 60,68
反应条件
1: 70 percent / polyphosphoric acid / 0.33 h / 110 °C
2: 60 percent / conc. HCl / ethanol / 8 h / Heating
View Scheme
参考文献
Daukshas, V. K.; Gaidyalis, P. G.; Labanauskas, L. K.; Gumbaragite, L. F.; Gasperavichene, G. A.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 8 p. 544 - 547
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 8 p. 32 - 34
