6,7,8-三氟-1,4-二氢-4-氧代-3-喹啉羧酸乙酯合成路线 （共 15 条）
反应条件
in diphenylether T=190°C; 0.416667 h; Microwave irradiation;
参考文献
Synthetic Communications, , vol. 39, # 24 p. 4375 - 4383
反应条件
caesium carbonate in dimethyl sulfoxide T=80°C; 4 h;
参考文献
Journal of Organic Chemistry, , vol. 60, # 12 p. 3928 - 3930
反应条件
sodium hydride in tetrahydrofuran T=0°C;
参考文献
Tetrahedron Letters, , vol. 33, # 26 p. 3733 - 3736
反应条件
1: 86 percent / 2 h / Heating 2: 83 percent / various solvent(s) / 6 h / 250 °C View Scheme
参考文献
Tetrahedron, , vol. 63, # 9 p. 2093 - 2097
反应条件
sodium hydride in N,N-dimethyl-formamide T=90°C;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 3 p. 1188 - 1200
反应条件
1: 80 percent / CH2Cl2 / 336 h / Ambient temperature 2: NaH / tetrahydrofuran / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 26 p. 3733 - 3736
反应条件
1: toluene / 2 h / 0 - 20 °C 2: sodium hydride / N,N-dimethyl-formamide / 90 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 3 p. 1188 - 1200
反应条件
1: acetic anhydride / 3 h / 120 °C 2: toluene / 2 h / 0 - 20 °C 3: sodium hydride / N,N-dimethyl-formamide / 90 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 3 p. 1188 - 1200
反应条件
1: 2 h / 110 - 120 °C 2: diphenylether / 8 h / 250 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1232 - 1244
反应条件
trichlorophosphate in toluene 2 h; RefluxLarge scale;
参考文献
Hao, Qun; Pan, Jing; Li, Yongjia; Cai, Zhengyan; Zhou, Weicheng
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 921 - 926
