2-氯-3-甲基-4-氟苯甲腈合成路线 （共 4 条）
反应条件
1: 2-chloro-4-fluoro-benzonitrile With lithium diisopropyl amide in tetrahydrofuran; hexanes T=-78 - -65°C; 6 h; 2: methyl iodide in tetrahydrofuran; hexanes T=-65 - -5°C; 14 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/124447 A2, 2006 ;
Location in patent: Page/Page column 45-46 ;
WO 2006/124447 A2
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=120°C; 2 h; Product distribution / selectivity;
参考文献
Schlienger, Nathalie; Thygesen, Mikkel Boas; Pawlas, Jan; Badalassi, Fabrizio; Lewinsky, Rasmus; Lund, Birgitte Winther; Olsson, Roger
Patent: US2006/160845 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=200°C; 0.0416667 h; Microwave irradiation;
参考文献
Schlienger, Nathalie; Lund, Birgitte W.; Pawlas, Jan; Badalassi, Fabrizio; Bertozzi, Fabio; Lewinsky, Rasmus; Fejzic, Alma; Thygesen, Mikkel B.; Tabatabaei, Ali; Bradley, Stefania Risso; Gardell, Luis R.; Piu, Fabrice; Olsson, Roger
Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7186 - 7191
反应条件
pyridine; oxalyl dichloride in N,N-dimethyl-formamide T=0 - 10°C; 1 h;
参考文献
WO2007/15567 A1, ;
Page/Page column 87-88 ;
