7-甲氧基-1,6-二甲基异喹啉-5,8-二酮合成路线 （共 32 条）
反应条件
1.1: 57 percent / NH2OH*HCl; AcONa / ethanol / 1 h / 85 °C
2.1: 49 percent / various solvent(s) / 1 h / 180 °C
3.1: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
4.1: PhLi / cyclohexane; diethyl ether; dioxane / 0.17 h / cooling
4.2: 64 percent / cyclohexane; diethyl ether; dioxane / 0.5 h / 20 °C
5.1: 85 percent / LiEt3BH / tetrahydrofuran / 0.17 h / cooling
6.1: 91 percent / H2 / Pd/C / ethanol / 2 h / 20 °C
7.1: 85 percent / salcomine; O2 / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Kuwabara, Nagako; Hayashi, Hiroyuki; Hiramatsu, Noriko; Choshi, Tominari; Kumemura, Teppei; Nobuhiro, Junko; Hibino, Satoshi
Tetrahedron, 2004 , vol. 60, # 13 p. 2943 - 2952
反应条件
1.1: 49 percent / various solvent(s) / 1 h / 180 °C
2.1: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
3.1: PhLi / cyclohexane; diethyl ether; dioxane / 0.17 h / cooling
3.2: 64 percent / cyclohexane; diethyl ether; dioxane / 0.5 h / 20 °C
4.1: 85 percent / LiEt3BH / tetrahydrofuran / 0.17 h / cooling
5.1: 91 percent / H2 / Pd/C / ethanol / 2 h / 20 °C
6.1: 85 percent / salcomine; O2 / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Kuwabara, Nagako; Hayashi, Hiroyuki; Hiramatsu, Noriko; Choshi, Tominari; Kumemura, Teppei; Nobuhiro, Junko; Hibino, Satoshi
Tetrahedron, 2004 , vol. 60, # 13 p. 2943 - 2952
反应条件
1: 91 percent / H2 / Pd/C / ethanol / 2 h / 20 °C
2: 85 percent / salcomine; O2 / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Kuwabara, Nagako; Hayashi, Hiroyuki; Hiramatsu, Noriko; Choshi, Tominari; Kumemura, Teppei; Nobuhiro, Junko; Hibino, Satoshi
Tetrahedron, 2004 , vol. 60, # 13 p. 2943 - 2952
反应条件
1: 85 percent / LiEt3BH / tetrahydrofuran / 0.17 h / cooling
2: 91 percent / H2 / Pd/C / ethanol / 2 h / 20 °C
3: 85 percent / salcomine; O2 / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Kuwabara, Nagako; Hayashi, Hiroyuki; Hiramatsu, Noriko; Choshi, Tominari; Kumemura, Teppei; Nobuhiro, Junko; Hibino, Satoshi
Tetrahedron, 2004 , vol. 60, # 13 p. 2943 - 2952
反应条件
trifluoroacetic acid in chloroform
3 h; Heating;
参考文献
Saito, Naoki; Tanaka, Chieko; Koizumi, Yu-Ichi; Suwanborirux, Khanit; Amnuoypol, Surattana; Pummangura, Sunibhond; Kubo, Akinori
Tetrahedron, 2004 , vol. 60, # 17 p. 3873 - 3881
反应条件
1: 69 percent / 1 M lithium triethylborohydride / tetrahydrofuran / 0.5 h / Ambient temperature
2: 30 percent / ceric ammonium nitrate (CAN), pyridine-2,6-dicarboxylic acid N-oxide / acetonitrile; H2O / 1 h / Ambient temperature
View Scheme
参考文献
Kubo; Nakahara; Inaba; Kitahara
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 10 p. 4056 - 4068
反应条件
1: 85 percent / NaOEt / ethanol / 7 h / -15 °C
2: toluene / 0.25 h / Ambient temperature
3: toluene / 0.5 h / Ambient temperature
4: toluene / 3 h / 160 °C
5: 40 percent / aq. LiOH / tetrahydrofuran / 12 h / Ambient temperature
6: 62 percent / diphenyl ether / 24 h / 180 °C
7: 50 percent / Ag2O, HNO3 / dioxane / 0.25 h / Ambient temperature
View Scheme
参考文献
Molina, Pedro; Vidal, Angel; Tovar, Fulgencio
Synthesis, 1997 , # 8 p. 963 - 966
反应条件
1: 62 percent / diphenyl ether / 24 h / 180 °C
2: 50 percent / Ag2O, HNO3 / dioxane / 0.25 h / Ambient temperature
View Scheme
参考文献
Molina, Pedro; Vidal, Angel; Tovar, Fulgencio
Synthesis, 1997 , # 8 p. 963 - 966
反应条件
1: 40 percent / aq. LiOH / tetrahydrofuran / 12 h / Ambient temperature
2: 62 percent / diphenyl ether / 24 h / 180 °C
3: 50 percent / Ag2O, HNO3 / dioxane / 0.25 h / Ambient temperature
View Scheme
参考文献
Molina, Pedro; Vidal, Angel; Tovar, Fulgencio
Synthesis, 1997 , # 8 p. 963 - 966
反应条件
1: toluene / 0.25 h / Ambient temperature
2: toluene / 0.5 h / Ambient temperature
3: toluene / 3 h / 160 °C
4: 40 percent / aq. LiOH / tetrahydrofuran / 12 h / Ambient temperature
5: 62 percent / diphenyl ether / 24 h / 180 °C
6: 50 percent / Ag2O, HNO3 / dioxane / 0.25 h / Ambient temperature
View Scheme
参考文献
Molina, Pedro; Vidal, Angel; Tovar, Fulgencio
Synthesis, 1997 , # 8 p. 963 - 966
