2-甲基-5-溴苯甲酸合成路线

21900-41-45-溴-2-甲氧基苄氯

参考文献

JANSSEN PHARMACEUTICA N.V.; MITSUBISHI TANABE PHARMA CORPORATION
Patent: WO2009/35969 A1, 2009 ;
Location in patent: Page/Page column 76 ;
WO 2009/035969 A1

79669-49-12-甲基-5-溴苯甲酸+

616-38-6碳酸二甲酯

19725-82-75-溴-2-(羧基甲基)苯甲酸

参考文献

Tsou, Hwei-Ru; Otteng, Mercy; Tran, Tritin; Floyd Jr., M. Brawner; Reich, Marvin; Birnberg, Gary; Kutterer, Kristina; Ayral-Kaloustian, Semiramis; Ravi, Malini; Nilakantan, Ramaswamy; Grillo, Mary; McGinnis, John P.; Rabindran, Sridhar K.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 12 p. 3507 - 3525

79669-49-12-甲基-5-溴苯甲酸

108-39-4间甲酚

参考文献

Jacobsen
Chemische Berichte, 1883 , vol. 16, p. 1964

67-56-1甲醇+

79669-49-12-甲基-5-溴苯甲酸

79669-50-42-甲基-5-溴苯甲酸甲酯

参考文献

ELI LILLY AND COMPANY
Patent: WO2005/73205 A1, 2005 ;
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WO 2005/073205 A1

79669-49-12-甲基-5-溴苯甲酸+

18107-18-1三甲基硅烷化重氮甲烷

79669-50-42-甲基-5-溴苯甲酸甲酯

参考文献

KUDOS PHARMACEUTICALS LIMITED
Patent: WO2008/23161 A1, 2008 ;
Location in patent: Page/Page column 116 ;
WO 2008/023161 A1

76006-33-23-溴-2-甲基苯甲酸+

79669-49-12-甲基-5-溴苯甲酸+

74-88-4甲基碘

99548-54-62-甲基-3-溴苯甲酸甲酯+

79669-50-42-甲基-5-溴苯甲酸甲酯

参考文献

ASTRAZENECA AB
Patent: WO2005/100351 A1, 2005 ;
Location in patent: Page/Page column 13; 16-17 ;
WO 2005/100351 A1

79669-49-12-甲基-5-溴苯甲酸+

74-88-4甲基碘

79669-50-42-甲基-5-溴苯甲酸甲酯

参考文献

HADIDA RUAH, SARA S.; Miller, Mark; Zhou, Jinglan; Bear, Brian; Grootenhuis, Peter
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79669-49-12-甲基-5-溴苯甲酸

79669-50-42-甲基-5-溴苯甲酸甲酯

参考文献

Genelabs Technologies, Inc.
Patent: US2009/226398 A1, 2009 ;

67-56-1甲醇+

76006-33-23-溴-2-甲基苯甲酸+

79669-49-12-甲基-5-溴苯甲酸

99548-54-62-甲基-3-溴苯甲酸甲酯+

79669-50-42-甲基-5-溴苯甲酸甲酯

参考文献

Wyeth
Patent: US2007/203116 A1, 2007 ;
Location in patent: Page/Page column 8; 10 ;
US 20070203116 A1

79669-49-12-甲基-5-溴苯甲酸

258886-04-3

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PRESIDENT AND FELLOWS OF HARVARD COLLEGE; MYERS, Andrew, G.; SI, Chong
Patent: WO2013/3315 A2, 2013 ;
Location in patent: Paragraph 00201 ;