2-甲基-5-溴苯甲酸甲酯合成路线 （共 22 条）
反应条件
1: With diazomethyl-trimethyl-silane in hexane T=20°C; 1.16667 h; 2: With acetic acid in hexane 0.75 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/73205 A1, 2005 ;
Location in patent: Page/Page column 27-28 ;
WO 2005/073205 A1
反应条件
methanol in diethyl ether; toluene T=0 - 20°C; 1 h;
参考文献
KUDOS PHARMACEUTICALS LIMITED
Patent: WO2008/23161 A1, 2008 ;
Location in patent: Page/Page column 116 ;
WO 2008/023161 A1
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 2 h;
参考文献
ASTRAZENECA AB
Patent: WO2005/100351 A1, 2005 ;
Location in patent: Page/Page column 13; 16-17 ;
WO 2005/100351 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
US2009/143381 A1, ;
Page/Page column 55 ;
反应条件
sulfuric acid in methanol; benzene
反应条件
bromine; potassium carbonate in methanol; water
反应条件
sulfuric acid 20 h; Heating / reflux;
参考文献
US2007/203116 A1, ;
Page/Page column 8; 10 ;
US 20070203116 A1
反应条件
1: ortho-methylbenzoic acid With bromine; iron T=20°C; 24 h; 2: methyl iodide With potassium carbonate in diethyl ether 0.5 h; Heating; Further stages.;
参考文献
Lartia, Remy; Allain, Clemence; Bordeau, Guillaume; Schmidt, Falk; Fiorini-Debuisschert, Celine; Charra, Fabrice; Teulade-Fichou, Marie-Paule
Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 1732 - 1744
反应条件
1: water; bromine / 140 °C 2: HCl View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 239, p. 84
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 106, p. 949
反应条件
1: ortho-methylbenzoic acid With bromine; iron T=0 - 20°C; 16 h; 2: methanol With sulfuric acid 15 h; Reflux;
参考文献
Herzog, Beat; Neier, Reinhard
Arkivoc, 2011 , vol. 2011, # 6 p. 29 - 44
