5-溴-2-溴甲苯甲酸甲酯合成路线 （共 8 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in chloroform 16 h; Heating / reflux;
参考文献
KUDOS PHARMACEUTICALS LIMITED
Patent: WO2008/23161 A1, 2008 ;
Location in patent: Page/Page column 116-117 ;
WO 2008/023161 A1
反应条件
2,2'-azo-bisisobutyronitrile in tetrachloromethane Suzuki reaction; 4 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/73205 A1, 2005 ;
Location in patent: Page/Page column 27-28 ;
WO 2005/073205 A1
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 20 h; Heating / reflux;
参考文献
US2007/203116 A1, ;
Page/Page column 8; 10 ;
US 20070203116 A1
反应条件
1: thionyl chloride / 0 - 20 °C 2: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 80 °C View Scheme
反应条件
1: bromine; iron / 16 h / 0 - 20 °C 2: thionyl chloride / 0 - 20 °C 3: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 80 °C View Scheme
反应条件
ammonia in tetrahydrofuran; methanol T=20°C; 0.666667 h;
参考文献
KUDOS PHARMACEUTICALS LIMITED
Patent: WO2008/23161 A1, 2008 ;
Location in patent: Page/Page column 117 ;
WO 2008/023161 A1
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide T=75°C; 2 h;
参考文献
Lartia, Remy; Allain, Clemence; Bordeau, Guillaume; Schmidt, Falk; Fiorini-Debuisschert, Celine; Charra, Fabrice; Teulade-Fichou, Marie-Paule
Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 1732 - 1744
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in dichloromethane
T=20°C; 16.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/73205 A1, 2005 ;
Location in patent: Page/Page column 68 ;
WO 2005/073205 A1
