5,6-二氢-4H-吡咯并[1,2-B]吡唑-2-羧酸合成路线 (共 3 条)
反应条件
water; sodium hydroxide in 1,4-dioxane T=65°C; 2.5 h;
参考文献
GENENTECH, INC.; Crawford, James John; Ortwine, Daniel Fred; Wei, BinQing; Young, Wendy B.
Patent: US2013/116246 A1, 2013 ;
Location in patent: Paragraph 0581 ;
反应条件
1: With potassium hydroxide in ethanol T=10 - 26°C; 4.2 - 5.5 h; 2: With hydrogenchloride in water pH=2;
参考文献
Wyeth Holdings Corporation
Patent: US2004/242874 A1, 2004 ;
Location in patent: Page 14-15 ;
反应条件
1: in ethylene glycol diethyl ether T=120 - 125°C; 8 h; Inert atmosphereLarge scale; 2: With sodium acetate in ethanol Large scale; Solvent;
参考文献
Organic Process Research and Development, , vol. 10, # 4 p. 712 - 716