3-(苄氧基)苯甲酸甲酯合成路线 （共 10 条）
反应条件
triphenylphosphine hydrobromide in acetonitrile T=100°C; 0.5 h; Microwave irradiationsealed tube;
参考文献
Ramanathan, Mani; Hou, Duen-Ren
Tetrahedron Letters, 2010 , vol. 51, # 47 p. 6143 - 6145
反应条件
1: With methanol; potassium hydroxide T=20°C; 18 h; 2: With sulfuric acid in water 0.5 h;
参考文献
UNIVERSITY OF GREENWICH
Patent: WO2009/90431 A1, 2009 ;
Location in patent: Page/Page column 34 ;
WO 2009/090431 A1
反应条件
1: 88.9 percent / NaBH4; I2 / tetrahydrofuran / 6 h / 70 °C 2: 98.5 percent / KMnO4; ZrOCl2*8H2O / tetrahydrofuran / 8 h / 20 °C / ultrasonification View Scheme
参考文献
Zhang, Wei-Ge; Zhao, Rui; Ren, Jian; Ren, Li-Xiang; Lin, Jin-Guang; Liu, Dai-Lin; Wu, Ying-Liang; Yao, Xin-Sheng
Archiv der Pharmazie, 2007 , vol. 340, # 5 p. 244 - 250
反应条件
sodium tetrahydroborate; iodine in tetrahydrofuran T=70°C; 6 h;
参考文献
Zhang, Wei-Ge; Zhao, Rui; Ren, Jian; Ren, Li-Xiang; Lin, Jin-Guang; Liu, Dai-Lin; Wu, Ying-Liang; Yao, Xin-Sheng
Archiv der Pharmazie, 2007 , vol. 340, # 5 p. 244 - 250
反应条件
potassium carbonate; potassium iodide in acetone
T=20°C; 24 h;
参考文献
UNIVERSITY OF GREENWICH
Patent: WO2009/90431 A1, 2009 ;
Location in patent: Page/Page column 32-33 ;
WO 2009/090431 A1
反应条件
potassium carbonate in acetone
2 h; Heating;
参考文献
Deberardinis, Albert M.; Banerjee, Upasana; Hadden, M. Kyle
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 7 p. 590 - 595
反应条件
1: 3-hydroxybenzoic acid methyl ester With potassium carbonate in DMF (N,N-dimethyl-formamide)
T=20°C; 0.75 h;
2: benzyl bromide in DMF (N,N-dimethyl-formamide)
T=20°C; 0.833333 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/68452 A1, 2005 ;
Location in patent: Page/Page column 37 ;
WO 2005/068452 A1
反应条件
1: conc. H2SO4 / 12 h / Heating
2: 39.1 g / K2CO3 / dimethylformamide / 16 h / 60 °C
View Scheme
参考文献
Zhang, Wei-Ge; Zhao, Rui; Ren, Jian; Ren, Li-Xiang; Lin, Jin-Guang; Liu, Dai-Lin; Wu, Ying-Liang; Yao, Xin-Sheng
Archiv der Pharmazie, 2007 , vol. 340, # 5 p. 244 - 250
参考文献
Forrest et al.
Journal of the Chemical Society, 1951 , p. 303
反应条件
1.1: 95 percent / KOH / tetrahydrofuran; H2O / 24 h
2.1: 1-methyl-imidazole; p-toluenesulfonyl chloride / acetonitrile
2.2: acetonitrile
3.1: 80 percent / Amberlyst(R) 15 / ethanol; H2O / Heating
View Scheme
参考文献
Schmidt, Rolf; Carrigan, Joseph G.; DeWolf, Christine E.
Canadian Journal of Chemistry, 2006 , vol. 84, # 10 p. 1411 - 1415
