1: (diethoxy-phosphoryl)-fluoro-acetic acid ethyl ester With sodium hydride in tetrahydrofuran T=20°C; 1.5 h; 2: isovaleraldehyde in tetrahydrofuran

1: With diethylzinc in hexane; dichloromethane T=20°C; 3 h; Inert atmosphere; 2: With ammonium chloride in hexane; dichloromethane optical yield given as percent destereoselective reaction;

1: ethyl 2,2-dibromo-2-fluoroacetate With diethylzinc; triphenylphosphine in tetrahydrofuran; hexane T=20 - 35°C; 0.166667 h; 2: isovaleraldehyde in tetrahydrofuran; hexane T=20°C; Wittig reaction; 0.166667 h; Further stages. Title compound not separated from byproducts.;