N-[4-(3-氨基-1H-吲唑-4-基)苯基]-N’-(2-氟-5-甲基苯基)脲合成路线 (共 6 条)
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate in ethanol; water Suzuki coupling; 6 h; Inert atmosphereReflux;
参考文献
Organic Process Research and Development, , vol. 13, # 6 p. 1419 - 1425
反应条件
potassium phosphate; 1,1'-bis-(di-tert-butylphosphino)ferrocene; palladium diacetate in ethanol; water T=55°C; Suzuki coupling; 1.5 h; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 13, # 6 p. 1419 - 1425
反应条件
1: CH2Cl2 / 0 - 20 °C 2: Na2CO3 / Pd(dppf)Cl2*CH2Cl2 / 1,2-dimethoxy-ethane; H2O / 16 h / 85 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 7 p. 1584 - 1597
反应条件
1: 90 percent / hydrazine monohydrate / butan-1-ol / 5 h / 105 - 110 °C 2: Na2CO3 / Pd(dppf)Cl2*CH2Cl2 / 1,2-dimethoxy-ethane; H2O / 16 h / 85 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 7 p. 1584 - 1597
反应条件
1: CH2Cl2 / 20 °C 2: Na2CO3 / Pd(dppf)Cl2*CH2Cl2 / 1,2-dimethoxy-ethane; H2O / 16 h / 85 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 7 p. 1584 - 1597
参考文献
WO2009/52231 A1, ;
Page/Page column 13-14 ;