3-氨基-2-(1H-3-吲哚)-丙酸甲酯合成路线 （共 7 条）
反应条件
hydrogen; nickel in ethanol
T=20°C; 20 h; atmospheric pressure;
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Giuli, Sandra; Giuliani, Arianna; Lucarelli, Laura; Marcantoni, Enrico; Sambri, Letizia; Torregiani, Elisabetta
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1941 - 1944
反应条件
1: 91 percent / CeCl3*7H2O; NaI; silica gel / acetonitrile / 4 h / 20 °C
2: H2 / Raney nickel / ethanol / 20 h / 20 °C / atmospheric pressure
View Scheme
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Giuli, Sandra; Giuliani, Arianna; Lucarelli, Laura; Marcantoni, Enrico; Sambri, Letizia; Torregiani, Elisabetta
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1941 - 1944
反应条件
1: 88 percent / H2 / Raney Ni (W-4) / 2585.7 Torr
2: 72 percent / 10 N NaOH / 8 h / Heating
3: SOCl2 / 18 h / Ambient temperature
View Scheme
参考文献
Safdy, Max E.; Kurchacova, Elva; Schut, Robert N.; Vidrio, Horacio; Hong, Enrique
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 723 - 730
反应条件
hydrogenchloride in 1,4-dioxane
12 h;
参考文献
Droste, Holger; Wieland, Theodor
Liebigs Annalen der Chemie, 1987 , p. 901 - 910
反应条件
1: 84 percent / diphenyl-azidophosphate, NEt3, molecular sieve / 2-methyl-propan-2-ol; H2O / 36 h / Heating
2: 40 percent / HCl / dioxane / 12 h
View Scheme
参考文献
Droste, Holger; Wieland, Theodor
Liebigs Annalen der Chemie, 1987 , p. 901 - 910
反应条件
1: 72 percent / 10 N NaOH / 8 h / Heating
2: SOCl2 / 18 h / Ambient temperature
View Scheme
参考文献
Safdy, Max E.; Kurchacova, Elva; Schut, Robert N.; Vidrio, Horacio; Hong, Enrique
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 723 - 730
反应条件
thionyl chloride
18 h; Ambient temperature;
参考文献
Safdy, Max E.; Kurchacova, Elva; Schut, Robert N.; Vidrio, Horacio; Hong, Enrique
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 723 - 730
