1-(2-三氟甲基苯基)乙醇合成路线 （共 15 条）
反应条件
dodecacarbonyltriiron; C52H58N4P2; hydrogen; potassium hydroxide in methanol T=45°C; P=37503.8 Torr; 10 h; enantioselective reaction;
参考文献
Li, Yanyun; Yu, Shenluan; Wu, Xiaofeng; Xiao, Jianliang; Shen, Weiyi; Dong, Zhenrong; Gao, Jingxing
Journal of the American Chemical Society, 2014 , vol. 136, # 10 p. 4031 - 4039
反应条件
[Ru(II)(η6-benzene)(μ-Cl)Cl]2; (R,R)-(-)-N,N'-dimethyl-1,2-diphenyl-1,2-ethylenyl-diphenyldithiourea; potassium tert-butylate T=82°C; 17 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 19 p. 3319 - 3326
反应条件
1: isopropyl alcohol With [Ru(1,5-cyclooctadiene)Cl2]x; (8R,9R)-9-amino-(9-deoxy)epiquinine T=20°C; 0.5 h; Inert atmosphere; 2: With potassium hydroxide 0.5 h; Inert atmosphere; 3: o-trifluoromethylacetophenone T=0°C; 96 h; Inert atmosphere; enantioselective reaction;
参考文献
Jiang, Heyan
Journal of Chemical Research, 2013 , vol. 37, # 12 p. 761 - 763
反应条件
1: With bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; (1R,2R)-1,2-bis(di[2-furyl]phosphanyl)cyclohexane; benzo[1,3,2]dioxaborole in ethylene glycol dimethyl ether; toluene T=-75°C; 1 h; 2: With potassium hydroxide; dihydrogen peroxide in ethylene glycol dimethyl ether Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 7 p. 1235 - 1238
反应条件
potassium hydroxide; water in toluene T=50°C; 1.5 h;
参考文献
EP1935866 A1, ;
Page/Page column 16-17 ;
反应条件
1: With benzo[1,3,2]dioxaborole; rhodium complex 2 in toluene T=20°C; Addition; Hydroboration; 2 h; 2: With sodium hydroxide; water; dihydrogen peroxide in toluene T=20°C; Oxidation; 2 h; Title compound not separated from byproducts;
参考文献
Chemistry - A European Journal, , vol. 5, # 4 p. 1320 - 1330
反应条件
1: 82 percent / tetrahydrofuran / 1 h / Ambient temperature 2: pyridine / 1.) RT, 24 h, 2.) 90 deg C, 6 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 112, # 15 p. 5741 - 5747
反应条件
1: pyridine / 1.) RT, 24 h, 2.) 90 deg C, 6 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 112, # 15 p. 5741 - 5747
反应条件
Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 112, # 15 p. 5741 - 5747
反应条件
phosphorus pentoxide in benzene 4 h; Heating;
参考文献
Mesnard, Danielle; Bernadou, Francoise; Miginiac, Leone
Journal of Chemical Research, Miniprint, 1981 , # 9 p. 3216 - 3245
