5-氯-1-环戊基-3-苯基苯并咪唑-2-酮合成路线 （共 3 条）
反应条件
1: 86 percent / CHCl3 / 20 h / Heating
2: 99.3 percent / EtONa / ethanol / 3 h / Heating
3: 1.) 50 percent NaH / 1.) DMF, 60 - 70 deg C, 30 min; 2.) DMF, 60 - 70 deg C, 10 h
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
1: 99.3 percent / EtONa / ethanol / 3 h / Heating
2: 1.) 50 percent NaH / 1.) DMF, 60 - 70 deg C, 30 min; 2.) DMF, 60 - 70 deg C, 10 h
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
sodium hydride
1.) DMF, 60 - 70 deg C, 30 min; 2.) DMF, 60 - 70 deg C, 10 h; Yield given. Multistep reaction;
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
