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乙二醇
甲醛
63148-62-9
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丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
酮啡诺
合成路线
（共 5 条）
31769-01-4
→
反应条件
79798-39-3
酮啡诺
反应条件
1: K2CO3 / CHCl3 / 24 h / 70 °C 2: 73 percent / Zn, NH4Cl / ethanol / 6 h / Heating View Scheme
参考文献
Manmade; Dalzell; Howes; Razdan
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1437 - 1440
1357173-13-7
→
反应条件
79798-39-3
酮啡诺
反应条件
1.1: platinum(IV) oxide; hydrogen / methanol / 20 h / 20 °C 2.1: hydrogenchloride / water / 1 h / 80 °C / Inert atmosphere 2.2: pH 9 3.1: acetic acid; zinc / 4 h / Inert atmosphere; Reflux View Scheme
参考文献
Ida, Yoshihiro; Nemoto, Toru; Hirayama, Shigeto; Fujii, Hideaki; Osa, Yumiko; Imai, Masayuki; Nakamura, Takashi; Kanemasa, Toshiyuki; Kato, Akira; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 949 - 961
1000410-52-5
→
反应条件
79798-39-3
酮啡诺
反应条件
1.1: hydrogenchloride / water / 1 h / 80 °C / Inert atmosphere 1.2: pH 9 2.1: acetic acid; zinc / 4 h / Inert atmosphere; Reflux View Scheme
参考文献
Ida, Yoshihiro; Nemoto, Toru; Hirayama, Shigeto; Fujii, Hideaki; Osa, Yumiko; Imai, Masayuki; Nakamura, Takashi; Kanemasa, Toshiyuki; Kato, Akira; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 949 - 961
16676-29-2
盐酸纳曲酮
→
反应条件
79798-39-3
酮啡诺
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 42 h / 20 °C / Inert atmosphere 2.1: palladium 10 on activated carbon; hydrogen; acetic acid / 19 h / 70 °C 3.1: toluene-4-sulfonic acid / toluene / 13 h / Inert atmosphere; Reflux 4.1: pyridine; thionyl chloride / 0 - 20 °C / Inert atmosphere 5.1: platinum(IV) oxide; hydrogen / methanol / 20 h / 20 °C 6.1: hydrogenchloride / water / 1 h / 80 °C / Inert atmosphere 6.2: pH 9 7.1: acetic acid; zinc / 4 h / Inert atmosphere; Reflux View Scheme
参考文献
Ida, Yoshihiro; Nemoto, Toru; Hirayama, Shigeto; Fujii, Hideaki; Osa, Yumiko; Imai, Masayuki; Nakamura, Takashi; Kanemasa, Toshiyuki; Kato, Akira; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 949 - 961
220556-50-3
→
反应条件
79798-39-3
酮啡诺
反应条件
1.1: pyridine; thionyl chloride / 0 - 20 °C / Inert atmosphere 2.1: platinum(IV) oxide; hydrogen / methanol / 20 h / 20 °C 3.1: hydrogenchloride / water / 1 h / 80 °C / Inert atmosphere 3.2: pH 9 4.1: acetic acid; zinc / 4 h / Inert atmosphere; Reflux View Scheme
参考文献
Ida, Yoshihiro; Nemoto, Toru; Hirayama, Shigeto; Fujii, Hideaki; Osa, Yumiko; Imai, Masayuki; Nakamura, Takashi; Kanemasa, Toshiyuki; Kato, Akira; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 949 - 961
