甲基(3S)-2,3,4,9-四氢-1H-beta-咔啉-3-羧酸酯合成路线 （共 3 条）
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; methanol
参考文献
Khan, Imran A.; Saxena, Anil K.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 13 p. 2617 - 2626
反应条件
trichloroisocyanuric acid; triethylamine in N,N-dimethyl-formamide
T=-20 - 0°C; 2 h; Inert atmosphere;
参考文献
Ikeda, Reiko; Kimura, Takanori; Tsutsumi, Tatsuya; Tamura, Syunsuke; Sakai, Norio; Konakahara, Takeo
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3506 - 3515
反应条件
1: trichloroisocyanuric acid; triethylamine / N,N-dimethyl-formamide / 2 h / -20 - 0 °C / Inert atmosphere
2: hydrazine hydrate / pentan-1-ol / 7 h / Reflux; Inert atmosphere
3: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere
4: acetic acid / water / 1 h / Reflux
View Scheme
参考文献
Ikeda, Reiko; Kimura, Takanori; Tsutsumi, Tatsuya; Tamura, Syunsuke; Sakai, Norio; Konakahara, Takeo
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3506 - 3515
