S-(-)-吲哚啉-2-羧酸合成路线 （共 38 条）
反应条件
potassium carbonate; copper(l) chloride in 1-methyl-pyrrolidin-2-one T=80 - 100°C; 3.5 - 4 h; Product distribution / selectivity;
参考文献
DSM IP Assets B.V.
Patent: EP1676838 A1, 2006 ;
Location in patent: Page/Page column 16 ;
反应条件
potassium carbonate; copper(l) chloride in water T=95°C; 40 h; Product distribution / selectivity;
参考文献
DSM IP ASSETS B.V.
Patent: WO2006/69799 A1, 2006 ;
Location in patent: Page/Page column 31-32 ;
反应条件
1: With sodium hydroxide; water T=20°C; 2: With hydrogenchloride; water T=20°C; pH=5;
参考文献
SK CORPORATION
Patent: WO2005/51910 A1, 2005 ;
Location in patent: Page/Page column 10-11 ;
反应条件
sodium hydroxide in water T=0 - 5°C; pH=2.9;
参考文献
WO2006/53440 A1, ;
Page/Page column 16 ;
反应条件
1: CsOH*H2O / cinchonine bromide derived chiral / 20 h 2: 69 percent / nBu3SnH; AIBN / benzene / 5 h / 85 °C 3: 77 percent / H2 / Pd/C / methanol / 48 h / 5171.62 Torr 4: 87 percent / aq. HCl / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 1 p. 163 - 168
反应条件
1: 77 percent / H2 / Pd/C / methanol / 48 h / 5171.62 Torr 2: 87 percent / aq. HCl / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 1 p. 163 - 168
反应条件
1: 69 percent / nBu3SnH; AIBN / benzene / 5 h / 85 °C 2: 77 percent / H2 / Pd/C / methanol / 48 h / 5171.62 Torr 3: 87 percent / aq. HCl / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 1 p. 163 - 168
反应条件
1: With sodium hydroxide in water; ethyl acetate pH=> 10; 2: With hydrogenchloride in water pH=4 - 5;
参考文献
US2009/253932 A1, ;
Page/Page column 3 ;
反应条件
hydrogenchloride in water 2 h; Product distribution / selectivity;
参考文献
Souvie, Jean-Claude; Lecouve, Jean-Pierre
Patent: US2006/183919 A1, 2006 ;
Location in patent: Page/Page column 3 ;
反应条件
hydrogenchloride 3 h; Heating;
参考文献
Kim, Dong H.; Guinosso, Charles J.; Buzby, George C.; Herbst, David R.; McCaully, Ronald J.; et al.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 394 - 403
