S-(-)-吲哚啉-2-羧酸合成路线 （共 38 条）
反应条件
P2O5; sodium hydroxide
反应条件
1: 100 percent / KOH / dimethylsulfoxide; H2O / Ambient temperature 2: 52 percent / Et3N / CH2Cl2 / 2.75 h / 0 - 20 °C 4: 1.) 4-(dimethylamino)pyridine 6: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 7: 100 percent / 6 N HCl / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 3 p. 394 - 403
反应条件
1: 52 percent / Et3N / CH2Cl2 / 2.75 h / 0 - 20 °C 3: 1.) 4-(dimethylamino)pyridine 5: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 6: 100 percent / 6 N HCl / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 3 p. 394 - 403
反应条件
1: 95 percent / NaOH / methanol; H2O / 1 h / Ambient temperature 3: 1.) 4-(dimethylamino)pyridine 5: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 6: 100 percent / 6 N HCl / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 3 p. 394 - 403
反应条件
1: With hydrogenchloride in water T=0°C; 0.5 h; 2: With sodium nitrite in water 1 h; 3: With ethanol in water T=55°C; 3 h;
参考文献
Liu, Jin-Qiang; Chen, Xin-Zhi; Ji, Baoming; Zhao, Bang-Tun
Research on Chemical Intermediates, 2013 , vol. 39, # 3 p. 1143 - 1152
反应条件
2: 1.) 4-(dimethylamino)pyridine 4: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 5: 100 percent / 6 N HCl / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 3 p. 394 - 403
反应条件
1: 1.) 4-(dimethylamino)pyridine 3: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 4: 100 percent / 6 N HCl / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 3 p. 394 - 403
反应条件
2: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 3: 100 percent / 6 N HCl / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 3 p. 394 - 403
反应条件
1: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 2: 100 percent / 6 N HCl / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 3 p. 394 - 403
反应条件
1.1: sulfuric acid; urea hydronitrate / 5 h / 0 - 60 °C 2.1: oxygen; potassium carbonate / water / 5 h / 120 °C / 3000.3 Torr / |Autoclave 3.1: 5 palladium on charcoal; hydrogen / water / 4 h / 60 °C / 3750.38 Torr / |Autoclave 4.1: hydrogenchloride / water / 0.5 h / 0 °C 4.2: 1 h 4.3: 3 h / 55 °C View Scheme
参考文献
Research on Chemical Intermediates, , vol. 39, # 3 p. 1143 - 1152
