反应条件
1: DBU / acetonitrile / 0 °C 2: 1.) methyl 2,2,2-trichloroacetimidate, Et3N, 2.) PPTS / 1.) MeCN, -20 to -15 deg C, 2.) MeOH, H2O, 20 deg C 3: 84 percent / H2O2 / H2O; tetrahydrofuran / 0 - 20 °C 4: 92 percent / Bu4NF / tetrahydrofuran / -5 - 0 °C 5: 88 percent / DIAD, PPh3 / tetrahydrofuran / 0 °C 6: 90 percent / tetrahydrofuran / 20 °C 7: Et3N / CH2Cl2 / Heating 8: TsOH / methanol / 20 °C 9: imidazole / dimethylformamide; CH2Cl2 / -60 °C 10: 91 percent / OsO4, NMO, H2O / acetone / 0 °C 11: 92 percent / TsOH / 20 °C 12: DMAP, Et3N / CH2Cl2 / 20 °C 13: Bu4NF / tetrahydrofuran / 20 °C 14: NaOH, H2O 15: 76 percent / cyclohexene / 5percent Pd/C / ethanol / Heating 16: 96 percent / HCl, H2O / methanol View Scheme
