反应条件
1: 54 percent / triphenylphosphine, diethyl azodicarboxylate / benzene / 12 h / Heating 2: 86 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature 3: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature 4: 80 percent / pyridine / 14 h / Ambient temperature 5: 1.) H2, 2.) Et3N / 1.) Pd(OH)2 / 1.) MeOH, 1 atm, 1 h, 2.) reflux, 1.5 h 6: 71 percent / a) conc. HCl, b) Dowex 1-X8, OH(1-)-form / a) MeOH, reflux, 30 min, b) H2O View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 1 p. 52 - 61
