反应条件
1: 90 percent / t-BuOOH, Ti(Oi-Pr)4, (+)-DIPT, molecular sieves 4 Angstroem / CH2Cl2; 2,2,4-trimethyl-pentane / -23 °C 2: 73 percent / NaN3 / dimethylformamide / 14 h / Ambient temperature 3: 1.) K3<Fe)CN)6>, K2CO3, (DHQ)2-PHAL, K2OsO4*2H2O, MeSO2NH2, 2.) pyridine / 1.) H2O-t-BuOH, r.t., 16 h, 2.) CH2Cl2, 0 deg C, 4 h; r.t., 10 h 4: 54 percent / H2 / 10percent Pd/C / ethanol / 7 h / Ambient temperature 5: 1.) BH3*Me2S, 2.) CF3COOH / 1.) THF, r.t., 2 h, 2.) H2O, r.t., 2.5 days View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 25 p. 7096 - 7099
