反应条件
1: 7 h / 130 °C 2: K2CO3 / ethanol / 72 h / 20 °C 3: Py, DMAP / 48 h / 20 °C 4: 1) AcOAg, Br2, 2) SOCl2, 3) 2-(tert-butylimino)-2-(diethylamino)-1,3-dimethylperhydro-1,3,2-diazaphosphorine on polystyrene 5: 1) 2-(tert-butylimino)-2-(diethylamino)-1,3-dimethylperhydro-1,3,2-diazaphosphorine on polystyrene, 2) Py, DMAP / 1) CH3CN, H2O, 100 deg C, 4.5 h, 2) 20 deg C, 2 d 6: 1) BH3*Me2S, 2) MeOH, K2CO3 / 1) THF, 20 deg C, 15 h, 2) H2O, 60 deg C, 2 h 7: 41 mg / H2 / Pd/C / tetrahydrofuran; H2O / 24 h / 20 °C / 760 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 6 p. 2128 - 2135
