(S)-(-)-2-氨基-1,1,3-三苯基-1-丙醇合成路线 （共 17 条）
反应条件
1: in diethyl ether T=60°C; 18 h; 2: With water in diethyl ether Cooling with ice;
参考文献
Campbell, Craig D.; Concellon, Carmen; Smith, Andrew D.
Tetrahedron Asymmetry, 2011 , vol. 22, # 7 p. 797 - 811
反应条件
in diethyl ether T=0°C; Inert atmosphere;
参考文献
Shen, Tianhua; Li, Junqi; Cui, Funa; Zhou, Xiaocong; Chen, Xiaoli; Song, Qingbao
Journal of the Chemical Society of Pakistan, 2013 , vol. 35, # 5 p. 1354 - 1358
反应条件
1: bromobenzene With magnesium in diethyl ether 0.5 h; Heating; 2: DL-phenylalanine ethyl ester in diethyl ether 0.5 h; Heating; Further stages.;
参考文献
Guo, Fengfeng; Chang, Dalu; Lai, Guoyin; Zhu, Tao; Xiong, Shunshun; Wang, Sujing; Wang, Zhiyong
Chemistry - A European Journal, 2011 , vol. 17, # 40 p. 11127 - 11130
反应条件
in diethyl ether T=20°C;
参考文献
Zhou, Zhongqiang; Guo, Yajing
Synthetic Communications, 2008 , vol. 38, # 5 p. 684 - 696
反应条件
1: bromobenzene With magnesium in diethyl ether 2: (L)-phenylalanine methyl ester hydrochloride in diethyl ether T=0 - 20°C;
参考文献
Da, Chao-Shan; Han, Zhi-jian; Ni, Ming; Yang, Fan; Liu, Da-Xue; Zhou, Yi-Feng; Wang, Rui
Tetrahedron Asymmetry, 2003 , vol. 14, # 6 p. 659 - 665
反应条件
chiral stationary phase including (R)-naphthylethyl-carbamate-functionalized CF6 in ethanol; n-heptane; trifluoroacetic acid T=20°C; Purification / work up;
参考文献
WO2010/148191 A2, ;
Page/Page column 45-49; 64 ;
反应条件
in tetrahydrofuran T=20°C;
参考文献
Ohga, Takahiko; Umeda, Satoshi; Kawanami, Yasuhiro
Tetrahedron, 2001 , vol. 57, # 23 p. 4825 - 4829
反应条件
diethyl ether; phenyl-magnesium bromide
参考文献
Journal of the Chemical Society, , p. 790
反应条件
1: L-phenylalanine With thionyl chloride in methanol T=-30 - 20°C; 2: 2 h; Heating; 3: Bromure de phenyl magnesium in tetrahydrofuran T=20°C; 24 h;
参考文献
Tetrahedron Letters, , vol. 46, # 5 p. 863 - 865
反应条件
1: bromobenzene With iodine; magnesium in diethyl ether Heating; 2: L-phenylalanine in diethyl ether Grignard reaction; Heating;
参考文献
Mueller, Simona; Afraz, Marcel Cyrus; De Gelder, Rene; Ariaans, Gerry J. A.; Kaptein, Bernard; Broxterman, Quirinus B.; Bruggink, Alle
European Journal of Organic Chemistry, 2005 , # 6 p. 1082 - 1096
