4-(2,6-二氯苯基)苯酚合成路线 （共 3 条）
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=95°C; Suzuki reaction;
参考文献
Edsall Jr., Richard J; Harris, Heather A; Manas, Eric S; Mewshaw, Richard E
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3457 - 3474
反应条件
1.1: 100 percent / imidazole / dimethylformamide / 20 °C
2.1: n-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C
2.2: triisopropyl borate / tetrahydrofuran / -78 - 20 °C
2.3: 65 percent / HCl / tetrahydrofuran; H2O / 0.08 h / 0 °C
3.1: 94 percent / Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 95 °C
View Scheme
参考文献
Edsall Jr., Richard J; Harris, Heather A; Manas, Eric S; Mewshaw, Richard E
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3457 - 3474
反应条件
1.1: n-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C
1.2: triisopropyl borate / tetrahydrofuran / -78 - 20 °C
1.3: 65 percent / HCl / tetrahydrofuran; H2O / 0.08 h / 0 °C
2.1: 94 percent / Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 95 °C
View Scheme
参考文献
Edsall Jr., Richard J; Harris, Heather A; Manas, Eric S; Mewshaw, Richard E
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3457 - 3474
