6-溴-2(1H)-喹唑啉酮合成路线 （共 4 条）
反应条件
in neat (no solvent) T=180°C; 5 h;
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
Location in patent: Page/Page column 37; 38 ;
反应条件
1: borane-THF / tetrahydrofuran / 0 - 20 °C 2: manganese(IV) oxide / dichloromethane / 20 °C 3: neat (no solvent) / 5 h / 180 °C View Scheme
反应条件
1: manganese(IV) oxide / dichloromethane / 20 °C 2: neat (no solvent) / 5 h / 180 °C View Scheme
反应条件
trichlorophosphate T=110°C; 5 h;
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
Location in patent: Page/Page column 37; 38 ;
