3-溴呋喃并[3,2-c]吡啶-4-胺合成路线 （共 7 条）
反应条件
ammonium hydroxide in 1,4-dioxane; water
T=150°C; 72 h;
参考文献
Lv, Yongcong; Li, Mengyuan; Liu, Ting; Tong, Linjiang; Peng, Ting; Wei, Lixin; Ding, Jian; Xie, Hua; Duan, Wenhu
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 5 p. 592 - 597
反应条件
1: 78 percent / piperidine; pyridine / 100 °C
2: 68 percent / DPPA; Et3N / tetrahydrofuran / 20 °C
3: toluene / 120 °C
4: I2 / 1,2-dichloro-benzene / 170 °C
5: 84 percent / POCl3 / 120 °C
6: Br2 / CCl4 / 20 °C
7: DBU / tetrahydrofuran; CCl4 / 20 °C
8: 47 percent / aq. NH3 / dioxane / 150 °C
View Scheme
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
反应条件
1: toluene / 120 °C
2: I2 / 1,2-dichloro-benzene / 170 °C
3: 84 percent / POCl3 / 120 °C
4: Br2 / CCl4 / 20 °C
5: DBU / tetrahydrofuran; CCl4 / 20 °C
6: 47 percent / aq. NH3 / dioxane / 150 °C
View Scheme
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
反应条件
1: 84 percent / POCl3 / 120 °C
2: Br2 / CCl4 / 20 °C
3: DBU / tetrahydrofuran; CCl4 / 20 °C
4: 47 percent / aq. NH3 / dioxane / 150 °C
View Scheme
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
反应条件
1: 68 percent / DPPA; Et3N / tetrahydrofuran / 20 °C
2: toluene / 120 °C
3: I2 / 1,2-dichloro-benzene / 170 °C
4: 84 percent / POCl3 / 120 °C
5: Br2 / CCl4 / 20 °C
6: DBU / tetrahydrofuran; CCl4 / 20 °C
7: 47 percent / aq. NH3 / dioxane / 150 °C
View Scheme
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
反应条件
1: I2 / 1,2-dichloro-benzene / 170 °C
2: 84 percent / POCl3 / 120 °C
3: Br2 / CCl4 / 20 °C
4: DBU / tetrahydrofuran; CCl4 / 20 °C
5: 47 percent / aq. NH3 / dioxane / 150 °C
View Scheme
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
反应条件
1: Br2 / CCl4 / 20 °C
2: DBU / tetrahydrofuran; CCl4 / 20 °C
3: 47 percent / aq. NH3 / dioxane / 150 °C
View Scheme
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
