1: methyl (E)-3-(3H-imidazol-4-yl)acrylate With triethylamine; benzenesulfonyl chloride in acetonitrile 8 h; Inert atmosphere; 2: methyl trifluoromethanesulfonate in acetonitrile 24 h; Inert atmosphere; 3: With N-methyl-N-butylamine in acetonitrile T=80°C; Inert atmosphereHeating; regioselective reaction;

1: trimethylamine / H2O / 44 h / 60 °C 2: hydrogen chloride / 21 h View Scheme

hydrogenchloride 21 h;