water; sodium hydroxide 0.5 h; Reflux;

sodium peroxodisulphate; silver nitrate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in water; acetonitrile T=80°C; 3 h; Inert atmosphereSchlenk techniqueCooling with liquid nitrogen;

1: With sodium hydroxide; water 6 h; Heating / reflux; 2: With hydrogenchloride in water T=0°C; Acidic conditions;

1: [bis(2-methoxyethyl)amino]-sulfur trifluoride / dichloromethane / 12 h / |Reflux 2: sodium hydroxide; water / 0.5 h / |Reflux View Scheme