DYNORPHIN A (1-11) AMIDE合成路线 (共 4 条)
反应条件
1: C29H30NO7Pol With piperidine in N,N-dimethyl-formamide
0.333333 h; solid phase reaction;
2: N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc) With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in dichloromethane; N,N-dimethyl-formamide
2 h; solid phase reaction;
3: N-(9-fluorenylmethoxycarbonyl)glycine; N-Fmoc-L-leucine; Fmoc–Pro–OH; Fmoc-L-phenylalanine; fmoc-L-Ile-OH; fmoc-O-tert-butyl-L-tyrosine; fmoc-L-Arg(Pbf)-OH Further stages;
参考文献
Patkar, Kshitij A.; Murray, Thomas F.; Aldrich, Jane V.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6814 - 6821
反应条件
Yield given. Multistep reaction;
参考文献
Kawasaki, Andrew M.; Knapp, Richard J.; Kramer, Thomas H.; Wire, William S.; Vasquez, Olga S.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1874 - 1879
参考文献
Lung; Collins; Stropova; Davis; Yamamura; Porreca; Hruby
Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1136 - 1141
反应条件
Multistep reaction.;
参考文献
Lu; Nguyen; Weltrowska; Berezowska; Lemieux; Chung; Schiller
Journal of Medicinal Chemistry, 2001 , vol. 44, # 19 p. 3048 - 3053