N,N,N',N',N'',N''-hexamethylphosphoric triamide; phenyllithium in tetrahydrofuran; diethyl ether 1.) -78 deg C, 30 min, 2.) reflux, 1 h;

lithium diisopropyl amide in tetrahydrofuran T=0 - 20°C; 2.5 h;

in methanol T=100°C; 6 h;

1: 80 percent / 40percent aq. NaOH / 0.5 h / 90 °C 2: 95 percent / hexamethylphosphoric triamide, phenyllithium / tetrahydrofuran; diethyl ether / 1.) -78 deg C, 30 min, 2.) reflux, 1 h View Scheme

1: 84 percent / acetic acid / 0.5 h 2: 80 percent / 40percent aq. NaOH / 0.5 h / 90 °C 3: 95 percent / hexamethylphosphoric triamide, phenyllithium / tetrahydrofuran; diethyl ether / 1.) -78 deg C, 30 min, 2.) reflux, 1 h View Scheme

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