N-甲基-N-亚硝基对甲苯磺酰胺合成路线 （共 111 条）
反应条件
1: N-methyl-N-nitroso-p-toluene-sulphonamide With potassium hydroxide in diethyl ether; diethylene glycol monoethyl ether; water 0.5 h; Heating; 2: (R)-2-isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester in diethyl ether T=20°C; Arndt-Eistert synthesis; Cooling with ice;
参考文献
Schjoth-Eskesen, Christina; Jensen, Henrik Helligso
Synthetic Communications, 2009 , vol. 39, # 18 p. 3243 - 3253
反应条件
sodium hydroxide in ethanol; water T=25°C; efeect of the alcohol concentration on rate constant; further alcohols; KineticsRate constant;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1861 - 1866
反应条件
1: N-methyl-N-nitroso-p-toluene-sulphonamide With potassium hydroxide in diethyl ether; water 2: 2-amino-5-methyl-benzoic acid in diethyl ether 1 h;
参考文献
Schuler, Elisabeth; Juanico, Nacho; Teixido, Jordi; Michelotti, Enrique L.; Borrell, Jose I.
Heterocycles, 2006 , vol. 67, # 1 p. 161 - 173
反应条件
1: N-methyl-N-nitroso-p-toluene-sulphonamide With potassium hydroxide in diethyl ether; ethanol; water T=65°C; 2: n-heptanoic acid chloride in diethyl ether; ethanol; dichloromethane; water T=0°C; 3: With hydrogen bromide in diethyl ether; ethanol; dichloromethane; water
参考文献
Su, Zhaoming; Rogers, Steven A.; McCall, W. Steve; Smith, Alicia C.; Ravishankar, Sindhu; Mullikin, Trey; Melander, Christian
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 12 p. 2814 - 2822
反应条件
potassium hydroxide in ethanol T=5 - 10°C; 3 h; Yields of byproduct given;
参考文献
Polivka, Zdenek; Metys, Jan; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 9 p. 2034 - 2049
反应条件
potassium hydroxide in ethanol T=5 - 10°C; 3 h; Yield given. Yields of byproduct given;
参考文献
Polivka, Zdenek; Metys, Jan; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 9 p. 2034 - 2049
反应条件
potassium hydroxide in methanol; diethyl ether
参考文献
Lightner,D.A.; Docks,E.L.
Tetrahedron, 1979 , vol. 35, p. 713 - 720
反应条件
potassium hydroxide in tetrahydrofuran; methanol; water
T=20°C; Overall yield = 97 percent; Overall yield = 232 mg;
参考文献
Mastronardi, Federica; Gutmann, Bernhard; Oliver Kappe
Organic Letters, 2013 , vol. 15, # 21 p. 5590 - 5593
反应条件
potassium hydroxide in methanol; diethyl ether
Ambient temperature;
参考文献
Della,G.W.; Cotsaris,E.; Hine,P.T.
Journal of the American Chemical Society, 1981 , vol. 103, p. 4131
反应条件
sodium hydroxide in 1,4-dioxane
T=25°C; Kinetics;
参考文献
Adam; Garcia-Rio; Leis; Moreira
Tetrahedron, 2006 , vol. 62, # 37 p. 8822 - 8829
