1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide
T=20°C; 2 h;
2: With potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/11190 A1, 2008 ;
Location in patent: Page/Page column 49 ;
WO 2008/011190 A1
1: 3-(trifluoromethyl)phenylsulfonyl chloride With sodium hydrogencarbonate; sodium sulfite in water
T=75°C; 1 h;
2: 1-bromopropanecarboxylic acid With sodium hydroxide in water
30 h; Reflux;
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: EP1953163 A1, 2008 ;
Location in patent: Page/Page column 10 ;
EP 1953163 A1
