N-({3-氯-4-[(4-氯苄基)磺酰基]苯基}氨基甲酰)-2,6-二氟苯甲酰胺合成路线 （共 30 条）
反应条件
in methanol
24 h; Heating;
参考文献
Deady, Leslie W.
Australian Journal of Chemistry, 1984 , vol. 37, # 5 p. 1135 - 1138
反应条件
Rhodium trichloride; sodium carbonate; triphenylphosphine
12 h; Heating;
参考文献
Grigg, Ronald; Mitchell, Thomas R. B.; Sutthivaiyakit, Somyote; Tongpenyai, Ngampong
Tetrahedron Letters, 1981 , vol. 22, # 41 p. 4107 - 4110
反应条件
1: 81 percent / acetic acid / 0.33 h / 150 - 160 °C
2: 48 percent / polyphosphoric acid / 2 h / 80 °C
View Scheme
参考文献
Deady, Leslie W.
Australian Journal of Chemistry, 1984 , vol. 37, # 5 p. 1135 - 1138
反应条件
1: sodium ethylate; ethanol
2: aqueous formaldehyde-solution; aq. NaOH solution
3: acetic acid; concentrated aqueous hydrochloric acid / Erwaermen des Reaktionsprodukts mit wss. Natronlauge und anschliessend mit wss. Mineralsaeure
View Scheme
参考文献
Haworth; Kelly
Journal of the Chemical Society, 1936 , p. 745
反应条件
1: 70 percent / K2CO3 / 3.5 h / 50 °C
2: 1.) aq. NaOH, 2.) acetic anhydride / 1.) MeOH, 3 d, 2.) reflux, 2 h
3: 75 percent / 72 h
4: 62 percent / CF3COOH / various solvent(s) / 1 h
5: 25percent aq. NH4OH / 1 h
View Scheme
参考文献
Condon; Petrillo Jr.; Ryono; Reid; Neubeck; Puar; Heikes; Sabo; Losee; Cushman; Ondetti
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 250 - 258
反应条件
1: 75 percent / 72 h
2: 62 percent / CF3COOH / various solvent(s) / 1 h
3: 25percent aq. NH4OH / 1 h
View Scheme
参考文献
Condon; Petrillo Jr.; Ryono; Reid; Neubeck; Puar; Heikes; Sabo; Losee; Cushman; Ondetti
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 250 - 258
反应条件
1: 1.) aq. NaOH, 2.) acetic anhydride / 1.) MeOH, 3 d, 2.) reflux, 2 h
2: 75 percent / 72 h
3: 62 percent / CF3COOH / various solvent(s) / 1 h
4: 25percent aq. NH4OH / 1 h
View Scheme
参考文献
Condon; Petrillo Jr.; Ryono; Reid; Neubeck; Puar; Heikes; Sabo; Losee; Cushman; Ondetti
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 250 - 258
反应条件
1: 62 percent / CF3COOH / various solvent(s) / 1 h
2: 25percent aq. NH4OH / 1 h
View Scheme
参考文献
Condon; Petrillo Jr.; Ryono; Reid; Neubeck; Puar; Heikes; Sabo; Losee; Cushman; Ondetti
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 250 - 258
反应条件
ammonium hydroxide
1 h;
参考文献
Condon; Petrillo Jr.; Ryono; Reid; Neubeck; Puar; Heikes; Sabo; Losee; Cushman; Ondetti
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 250 - 258
反应条件
sulfuric acid in benzene 18 h; Heating;
参考文献
Condon; Petrillo Jr.; Ryono; Reid; Neubeck; Puar; Heikes; Sabo; Losee; Cushman; Ondetti
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 250 - 258
