potassium hydroxide in ethanol; water 1.33333 h; Heating;

potassium hydroxide in ethanol; water 1 h; Heating;

1: 68.7 percent / sodium / ethanol / 1 h / Ambient temperature 2: 1.) POCl3 / 1.) 0-5 deg C then room temp. 15 min., 2.) DMF, 4 h., 40 deg C 3: piperidine / benzene / 4 h / Heating 4: 73 percent / KOH / ethanol; H2O / 1.33 h / Heating View Scheme

1: 1.) POCl3 / 1.) 0-5 deg C then room temp. 15 min., 2.) DMF, 4 h., 40 deg C 2: piperidine / benzene / 4 h / Heating 3: 73 percent / KOH / ethanol; H2O / 1.33 h / Heating View Scheme