5-甲基-4-硝基-N-(苯基甲基)-1H-吡唑-3-甲酰胺合成路线 （共 3 条）
反应条件
1: NaBH4 / 10percent Pd/C 2: NaNO2, AcOH 3: 1.) hexamethyldisilazane, ammonium sulfate, 2.) Me3SiCl, CF3SO3Cl / 1.) acetonitrile, reflux, 2.) acetonitrile, reflux, 3 h 4: 80 percent / NH3 / methanol / 24 h / 4 °C View Scheme
参考文献
Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 917 - 924
反应条件
in chloroform
Ambient temperature;
参考文献
Baraldi; Guarneri; Moroder; Simoni
Synthesis, 1981 , vol. No.9, p. 727 - 729
反应条件
1: 70 percent / NaBH4 / 10percent Pd/C / methanol; H2O / 3 h
2: 65 percent / 5 h / 180 °C
View Scheme
参考文献
Baraldi; Guarneri; Moroder; Simoni
Synthesis, 1981 , vol. No.9, p. 727 - 729
