copper(l) iodide; [palladium(II)(bis(triphenylphosphanyl))dichloride]; diisopropylamine in tetrahydrofuran T=80°C; Sonogashira coupling; 4.5 h; Inert atmosphere;

tin(ll) chloride in acetic acid

bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium hydroxide in tetrahydrofuran; N,N-dimethyl-formamide Sonogashira Cross-Coupling;

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / tetrahydrofuran / 8 h / |Reflux 2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium hydroxide / tetrahydrofuran; N,N-dimethyl-formamide View Scheme

potassium tert-butylate; bromine 1) CHCl3, 1 h, 2) THF, 30 min, reflux; Yield given. Multistep reaction;