5-氯-1H-吡咯并[2,3-C]吡啶-2-甲酸乙酯合成路线 （共 6 条）
反应条件
iron; ammonium chloride in tetrahydrofuran; ethanol T=20°C; 2 h; Reflux;
参考文献
JANSSEN RandD IRELAND; COOYMANS, Ludwig Paul; DEMIN, Samuel Dominique; HU, Lili; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; TAHRI, Abdellah; VENDEVILLE, Sandrine Marie Helene
Patent: WO2012/80450 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
iron in acetic acid T=60°C; 6 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/97129 A2, 2005 ;
Location in patent: Page/Page column 177 ;
WO 2005/097129 A2
反应条件
1: potassium ethanolate / diethyl ether / 16 h 2: iron / acetic acid / 6 h / 60 °C View Scheme
参考文献
WO2005/97129 A2, ;
WO 2005/097129 A2
反应条件
1.1: nitric acid; sulfuric acid / 22 h / 0 - 100 °C 1.2: 20 °C / pH 4 - 5 2.1: copper dichloride / N,N-dimethyl-formamide / 16.5 h / 60 - 110 °C 3.1: potassium ethanolate / diethyl ether / 16 h 4.1: iron / acetic acid / 6 h / 60 °C View Scheme
参考文献
WO2005/97129 A2, ;
WO 2005/097129 A2
反应条件
1: copper dichloride / N,N-dimethyl-formamide / 16.5 h / 60 - 110 °C 2: potassium ethanolate / diethyl ether / 16 h 3: iron / acetic acid / 6 h / 60 °C View Scheme
参考文献
WO2005/97129 A2, ;
WO 2005/097129 A2
反应条件
sodium hydroxide; water in ethanol 2 h; Heating / reflux;
参考文献
Prosidion Ltd
Patent: WO2006/67532 A1, 2006 ;
Location in patent: Page/Page column 19 ;
WO 2006/067532 A1
