反应条件
1: 1.) LDA / 1.) THF, hexane, HMPA, 0 deg C, 30 min, 2.) THF, hexane, HMPA, RT, 90 min
2: dimethylformamide / 4.5 h / 50 - 65 °C
3: MeONa / dimethylformamide / 2.5 h / 90 - 100 °C
4: 95 percent / conc. H2SO4 / 0.25 h / Heating
View Scheme
参考文献
Robertson, David W.; Beedle, E. E.; Swartzendruber, John K.; Jones, Noel D.; Elzey, T. K.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 635 - 640
