6-氯-3,4-二氢-2,2-二甲基-2H-1-苯并吡喃-4-酮合成路线 （共 20 条）
反应条件
pyrrolidine in methanol
T=25°C;
参考文献
Sebille, Sophie; De Tullio, Pascal; Becker, Benedicte; Antoine, Marie-Helene; Boverie, Stephane; Pirotte, Bernard; Lebrun, Philippe
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 614 - 621
参考文献
Eisai Co., Ltd.
Patent: US4540704 A1, 1985 ;
反应条件
ethylene glycol
T=180°C;
参考文献
Ariamala, G.; Balasubramanian, K. K.
Tetrahedron, 1989 , vol. 45, # 1 p. 309 - 318
反应条件
ethylene glycol
T=180°C; 0.0833333 h;
参考文献
Ariamala, G.; Balasubramanian, K. K.
Tetrahedron, 1989 , vol. 45, # 1 p. 309 - 318
反应条件
zinc in acetic acid
0.5 h; Heating;
参考文献
Hepworth, John D.; Jones, Terry K.; Livingstone, Robert
Tetrahedron, 1981 , vol. 37, # 15 p. 2613 - 2616
反应条件
in ethylene glycol
T=180°C; 0.0833333 h; Heating;
参考文献
Ariamala, G.; Balasubramanian, K.K.
Tetrahedron Letters, 1988 , vol. 29, # 28 p. 3487 - 3488
反应条件
nickel in ethanol
1 h; Ambient temperature;
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
反应条件
pyrrolidine in toluene
1) 24 h, 2) heating;
参考文献
Kabbe, Hans-Joachim; Widdig, Arno
Angewandte Chemie, 1982 , vol. 94, # 4 p. 254 - 262
反应条件
1: 92 percent / Et3N / CH2Cl2 / 0.5 h / -15 - 23 °C
2: 70.4 percent / formic acid; Et3N; 1,3-bis(diphenylphosphanyl)propane / palladium(II) acetate / dimethylformamide / 0.25 h
View Scheme
参考文献
Koever, Jozsef; Antus, Sandor
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2005 , vol. 60, # 7 p. 792 - 796
反应条件
aluminium trichloride
T=100°C; 3 h;
参考文献
Hepworth, John D.; Jones, Terry K.; Livingstone, Robert
Tetrahedron, 1981 , vol. 37, # 15 p. 2613 - 2616
