6-氯-3,4-二氢-2,2-二甲基-2H-1-苯并吡喃-4-酮合成路线 （共 20 条）
反应条件
mercury(II) trifluoroacetate in trifluoroacetic acid
Heating;
参考文献
Gopalsamy, Ariamala; Balasubramanian, K. K.
Journal of the Chemical Society, Chemical Communications, 1988 , # 1 p. 34 - 35
反应条件
1: 72 g / AlCl3 / 2 h / 160 °C
2: 79 percent / pyrrolidine / methanol / 25 °C
View Scheme
参考文献
Sebille, Sophie; De Tullio, Pascal; Becker, Benedicte; Antoine, Marie-Helene; Boverie, Stephane; Pirotte, Bernard; Lebrun, Philippe
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 614 - 621
反应条件
1: 91 percent / N,N-dimethylaniline / 1 h / 200 °C
2: 46 percent / Raney-Ni / ethanol / 1 h / Ambient temperature
View Scheme
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
反应条件
1: Br2, aq. NaOH / 1,2-dimethoxy-ethane
2: 70 percent / ethylene glycol / 180 °C
View Scheme
参考文献
Ariamala, G.; Balasubramanian, K. K.
Tetrahedron, 1989 , vol. 45, # 1 p. 309 - 318
反应条件
1: 92 percent / KOH / methanol / 1 h / Heating
2: Raney-Ni / ethanol / Ambient temperature
View Scheme
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
反应条件
nickel in ethanol
Ambient temperature;
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
反应条件
1: 1.) ether, boiling for 4 h 2.) acetic acid, boiling for 1 h
2: 92 percent / Br2 / CHCl3 / 10 °C
3: 91 percent / acetone; H2O / 24 h / Heating
4: 65 percent / CrO3 / H2O; acetic acid / 3 h / 55 - 60 °C
5: 18 percent / Zn dust / acetic acid / 0.5 h / Heating
View Scheme
参考文献
Hepworth, John D.; Jones, Terry K.; Livingstone, Robert
Tetrahedron, 1981 , vol. 37, # 15 p. 2613 - 2616
反应条件
1: 92 percent / Br2 / CHCl3 / 10 °C
2: 91 percent / acetone; H2O / 24 h / Heating
3: 65 percent / CrO3 / H2O; acetic acid / 3 h / 55 - 60 °C
4: 18 percent / Zn dust / acetic acid / 0.5 h / Heating
View Scheme
参考文献
Hepworth, John D.; Jones, Terry K.; Livingstone, Robert
Tetrahedron, 1981 , vol. 37, # 15 p. 2613 - 2616
反应条件
1: 65 percent / CrO3 / H2O; acetic acid / 3 h / 55 - 60 °C
2: 18 percent / Zn dust / acetic acid / 0.5 h / Heating
View Scheme
参考文献
Hepworth, John D.; Jones, Terry K.; Livingstone, Robert
Tetrahedron, 1981 , vol. 37, # 15 p. 2613 - 2616
反应条件
1: 91 percent / acetone; H2O / 24 h / Heating
2: 65 percent / CrO3 / H2O; acetic acid / 3 h / 55 - 60 °C
3: 18 percent / Zn dust / acetic acid / 0.5 h / Heating
View Scheme
参考文献
Hepworth, John D.; Jones, Terry K.; Livingstone, Robert
Tetrahedron, 1981 , vol. 37, # 15 p. 2613 - 2616
