N-[6-甲氧基-4-甲基-5-[3-(三氟甲基)苯氧基]喹啉-8-基]戊烷-1,2-二胺合成路线 （共 8 条）
反应条件
1: hydrogenchloride; water / ethanol / Reflux
2: phosphoric acid / 100 °C
3: 10 palladium on activated charcoal; hydrazine hydrate / ethanol / Reflux
4: sodium tetrahydroborate; acetic acid / 20 °C
5: hydrazine hydrate / ethanol / Reflux
6: ethanol
View Scheme
参考文献
Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1701 - 1704
反应条件
1: phosphoric acid / 100 °C
2: 10 palladium on activated charcoal; hydrazine hydrate / ethanol / Reflux
3: sodium tetrahydroborate; acetic acid / 20 °C
4: hydrazine hydrate / ethanol / Reflux
5: ethanol
View Scheme
参考文献
Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1701 - 1704
反应条件
1: potassium hydroxide / N,N-dimethyl-formamide / 100 °C
2: hydrogenchloride; water / ethanol / Reflux
3: phosphoric acid / 100 °C
4: 10 palladium on activated charcoal; hydrazine hydrate / ethanol / Reflux
5: sodium tetrahydroborate; acetic acid / 20 °C
6: hydrazine hydrate / ethanol / Reflux
7: ethanol
View Scheme
参考文献
Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1701 - 1704
反应条件
1: potassium hydroxide / N,N-dimethyl-formamide / 100 °C
2: hydrogenchloride; water / ethanol / Reflux
3: phosphoric acid / 100 °C
4: 10 palladium on activated charcoal; hydrazine hydrate / ethanol / Reflux
5: sodium tetrahydroborate; acetic acid / 20 °C
6: hydrazine hydrate / ethanol / Reflux
7: ethanol
View Scheme
参考文献
Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1701 - 1704
反应条件
1: sodium tetrahydroborate; acetic acid / 20 °C
2: hydrazine hydrate / ethanol / Reflux
3: ethanol
View Scheme
参考文献
Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1701 - 1704
反应条件
1: 10 palladium on activated charcoal; hydrazine hydrate / ethanol / Reflux
2: sodium tetrahydroborate; acetic acid / 20 °C
3: hydrazine hydrate / ethanol / Reflux
4: ethanol
View Scheme
参考文献
Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1701 - 1704
参考文献
Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1701 - 1704
反应条件
potassium hydroxide in 2-ethoxy-ethanol
参考文献
The United States of America as represented by the Secretary of the Army
Patent: US4431807 A1, 1984 ;
