3-苯甲酰基-2-氯吡啶合成路线 （共 16 条）
反应条件
ammonium hydroxide T=100°C; 2 h;
参考文献
Trecourt, Francois; Marsais, Francis; Guengoer, Timur; Queguiner, Guy
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 9 p. 2409 - 2415
反应条件
1: 56 percent / aq. NH4OH / 110 °C 2: 96 percent / NH2NH2*H2O; KOH / ethane-1,2-diol / 2 h / 200 °C View Scheme
参考文献
Andres, J Ignacio; Alonso, Jose M; Fernandez, Javier; Iturrino, Laura; Martinez, Pedro; Meert, Theo F; Sipido, Victor K
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 24 p. 3573 - 3577
反应条件
1: alpha-chloropyridine With N,N,N',N,-tetramethylethylenediamine; (TMP)2CuLi·LiCl in tetrahydrofuran
T=20°C; 2 h;
2: benzoyl chloride in tetrahydrofuran
T=20°C;
参考文献
Marquise, Nada; Harford, Philip J.; Chevallier, Floris; Roisnel, Thierry; Dorcet, Vincent; Gagez, Anne-Laure; Sable, Sophie; Picot, Laurent; Thiery, Valerie; Wheatley, Andrew E.H.; Gros, Philippe C.; Mongin, Florence
Tetrahedron, 2013 , vol. 69, # 47 p. 10123 - 10133
反应条件
chromium(VI) oxide in acetone
3 h; Ambient temperature;
参考文献
Trecourt, Francois; Marsais, Francis; Guengoer, Timur; Queguiner, Guy
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 9 p. 2409 - 2415
反应条件
dichloromethane; AcOF in monofluoro-trichloromethane
Ambient temperature;
参考文献
Hebel, David; Rozen, Shlomo
Journal of Organic Chemistry, 1988 , vol. 53, # 5 p. 1123 - 1125
反应条件
1: alpha-chloropyridine With lithium diisopropyl amide
2: N,N-dimethyl benzamide in tetrahydrofuran
T=-78°C;
参考文献
Kobayashi, Kazuhiro; Suzuki, Teruhiko; Horiuchi, Mai; Shiroyama, Yasuhiko; Konishi, Hisatoshi
Synthesis, 2011 , # 18 art. no. F53211SS, p. 2897 - 2906
反应条件
hydrogenchloride; magnesium
参考文献
Lacer, S.A.
Patent: US4614833 A1, 1986 ;
参考文献
Hebel, David; Rozen, Shlomo
Journal of Organic Chemistry, 1991 , vol. 56, # 22 p. 6298 - 6301
反应条件
in tetrahydrofuran
T=-20 - 20°C;
参考文献
Takayama, Kazuhisa; Iwata, Masahiro; Hisamichi, Hiroyuki; Okamoto, Yoshinori; Aoki, Motonori; Niwa, Akira
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 8 p. 1050 - 1059
反应条件
1.1: PhLi; diisopropylamine / tetrahydrofuran / 1 h / -40 °C
1.2: 75 percent / 0.75 h / -70 °C
2.1: 86 percent / CrO3 / acetone / 3 h / -30 - 20 °C
View Scheme
参考文献
Andres, J Ignacio; Alonso, Jose M; Fernandez, Javier; Iturrino, Laura; Martinez, Pedro; Meert, Theo F; Sipido, Victor K
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 24 p. 3573 - 3577
