3-苯甲酰基-2-氯吡啶合成路线 （共 16 条）
反应条件
1.1: PhLi; diisopropylamine / tetrahydrofuran / 1 h / -40 °C
1.2: 75 percent / 0.75 h / -70 °C
2.1: 86 percent / CrO3 / acetone / 3 h / -30 - 20 °C
View Scheme
参考文献
Andres, J Ignacio; Alonso, Jose M; Fernandez, Javier; Iturrino, Laura; Martinez, Pedro; Meert, Theo F; Sipido, Victor K
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 24 p. 3573 - 3577
参考文献
Lynch; Khan; Teo; Pedrotti
Canadian Journal of Chemistry, 1988 , vol. 66, # 3 p. 420-428
反应条件
1: acetic acid, 30percent hydrogen peroxide / 10 h / 50 °C
2: POCl2 / 6 h / Heating
View Scheme
参考文献
Lynch; Khan; Teo; Pedrotti
Canadian Journal of Chemistry, 1988 , vol. 66, # 3 p. 420-428
反应条件
sodium borohydride in ethanol; water
参考文献
Lacer, S.A.
Patent: US4614833 A1, 1986 ;
反应条件
in water
T=100°C; 4 h;
参考文献
Takayama, Kazuhisa; Iwata, Masahiro; Hisamichi, Hiroyuki; Okamoto, Yoshinori; Aoki, Motonori; Niwa, Akira
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 8 p. 1050 - 1059
反应条件
palladium diacetate; potassium carbonate; PCy3∙HBF4 in N,N-dimethyl-formamide
T=130°C; 48 h;
参考文献
Marquise, Nada; Harford, Philip J.; Chevallier, Floris; Roisnel, Thierry; Dorcet, Vincent; Gagez, Anne-Laure; Sable, Sophie; Picot, Laurent; Thiery, Valerie; Wheatley, Andrew E.H.; Gros, Philippe C.; Mongin, Florence
Tetrahedron, 2013 , vol. 69, # 47 p. 10123 - 10133
