1: aq. KHCO3 / methanol View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: NBS; AgNO₃ / acetone / 0.5 h / Ambient temperature<br />2: 37 percent / AgNO₃ / various solvent(s) / 20 h / 60 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 87 percent / NBS; AgNO₃ / acetone / 0.5 h / Ambient temperature<br />2: 56 percent / AgNO₃ / various solvent(s) / 7 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 87 percent / NBS; AgNO₃ / various solvent(s) / 0.5 h / Ambient temperature<br />2: 29 percent / AgNO₃ / various solvent(s) / 17 h / 60 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 53 percent / pyridine / 0.5 h / 0 &deg;C<br />2: 87 percent / NBS; AgNO₃ / various solvent(s) / 0.5 h / Ambient temperature<br />3: 29 percent / AgNO₃ / various solvent(s) / 17 h / 60 &deg;C<br /> <br /> &nbsp;