(-)-3,4,5,6-四氢-6-(2-甲基-1-丙烯基) -1H-氮杂卓并(5,4,3-cd)吲哚合成路线 （共 13 条）
反应条件
1.1: 9-BBN / tetrahydrofuran / 23 °C
1.2: 0 - 23 °C
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0 - 23 °C
3.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 23 °C
3.2: 70 °C
View Scheme
参考文献
Behenna, Douglas C.; Krishnan, Shyam; Stoltz, Brian M.
Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2152 - 2154
反应条件
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0 - 23 °C
2.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 23 °C
2.2: 70 °C
View Scheme
参考文献
Behenna, Douglas C.; Krishnan, Shyam; Stoltz, Brian M.
Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2152 - 2154
反应条件
1.1: tributylphosphine; di-isopropyl azodicarboxylate; ammonia / toluene / -78 - -20 °C
2.1: palladium on carbon; hydrogen / methanol / 23 °C
3.1: triethylamine / dichloromethane / 0 - 23 °C
4.1: pyridinium tribromide / dichloromethane / 0 - 23 °C
5.1: tetrakis(triphenylphosphine) palladium(0) / toluene / 100 °C
6.1: trichlorophosphate / pyridine / 0 - 23 °C
7.1: 9-BBN / tetrahydrofuran / 23 °C
7.2: 0 - 23 °C
8.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0 - 23 °C
9.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 23 °C
9.2: 70 °C
View Scheme
参考文献
Behenna, Douglas C.; Krishnan, Shyam; Stoltz, Brian M.
Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2152 - 2154
