1: 1.) LDA / 1.) THF, -78 deg C, 1 h then 0 deg C, 5 h; 2.) THF, -78 deg C, 3.5 h 2: 63 percent / sodium metaperiodate / tetrahydrofuran; methanol; H2O / 2.5 h / Ambient temperature 3: 95 percent / 0.4M perchloric acid, N-bromoacetamide / dioxane / 15 h / Ambient temperature 4: 87 percent / potassium acetate / ethanol; dioxane / 19 h / Heating 5: 48percent hydrofluoric acid / ethanol; tetrahydrofuran / 20 h / 0 °C View Scheme