5-(氯甲基)-1,2-恶唑-3-甲酰氯合成路线 （共 6 条）
反应条件
pyridine; thionyl chloride
10 h; Heating / reflux;
参考文献
Abbott GmbH and Co., KG
Patent: US6740647 B1, 2004 ;
Location in patent: Page column 34 ;
US 6740647 B1
反应条件
thionyl chloride
T=80°C; 72 h;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 148 ;
WO 2010/142801 A1
反应条件
1: CCl4 / 1 h / Heating
2: N-bromosuccinimide, benzoyl peroxide / CCl4 / 1.5 h / Heating; Irradiation
3: 4 N HCl / tetrahydrofuran / 0.08 h / Heating
4: (COCl)2 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Sircar, Jagadish C.; Capiris, Thomas; Bobovski, Thomas P.; Schwender, Charles F.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5723 - 5727
反应条件
1: N-bromosuccinimide, benzoyl peroxide / CCl4 / 1.5 h / Heating; Irradiation
2: 4 N HCl / tetrahydrofuran / 0.08 h / Heating
3: (COCl)2 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Sircar, Jagadish C.; Capiris, Thomas; Bobovski, Thomas P.; Schwender, Charles F.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5723 - 5727
反应条件
1: 4 N HCl / tetrahydrofuran / 0.08 h / Heating
2: (COCl)2 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Sircar, Jagadish C.; Capiris, Thomas; Bobovski, Thomas P.; Schwender, Charles F.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5723 - 5727
反应条件
oxalyl dichloride in tetrahydrofuran
2 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Sircar, Jagadish C.; Capiris, Thomas; Bobovski, Thomas P.; Schwender, Charles F.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5723 - 5727
