5-三氟甲基吡啶-2-羧酸合成路线 （共 8 条）
反应条件
n-butyllithium in toluene T=-75°C; 2 h;
参考文献
European Journal of Organic Chemistry, , # 8 p. 1559 - 1568
反应条件
n-butyllithium in toluene T=-75°C; 2 h;
参考文献
European Journal of Organic Chemistry, , # 8 p. 1559 - 1568
反应条件
1: 82 percent / chlorotrimethylsilane; sodium iodide / various solvent(s) / 75 h / Heating 2: 47 percent / butyllithium / toluene / 2 h / -75 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 8 p. 1559 - 1568
反应条件
thionyl chloride Reflux;
参考文献
US2012/316147 A1, ;
Page/Page column 76 ;
反应条件
1: thionyl chloride / Reflux 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / Reflux 3: trichlorophosphate / 0 - 50 °C View Scheme
参考文献
US2012/316147 A1, ;
WO2012/168350 A1, ;
WO 2012/168350 A1
反应条件
diphenyl phosphoryl azide; triethylamine
T=90°C; Curtius Rearrangement; 3 h;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2005/51390 A1, 2005 ;
Location in patent: Page/Page column 24 ;
WO 2005/051390 A1
