3-氯-2-氰基-5-三氟甲基吡啶合成路线 （共 14 条）
反应条件
4-(N,N-dimethlyamino)pyridine in water; anhydrous propionitrile T=20°C; 5 h;
参考文献
US6699993 B1, ;
Page column 4 ;
反应条件
in dimethyl sulfoxide T=30°C; 0.833333 h;
参考文献
WO2005/47279 A1, ;
Page/Page column 56 ;
WO 2005/047279 A1
反应条件
1: 2,3-dichloro-5-(trifluoromethyl)-pyridine With 4-(N,N-dimethlyamino)pyridine in anhydrous propionitrile Heating / reflux; 2: sodium cyanide in water; anhydrous propionitrile 5 h;
参考文献
WO2008/118718 A2, ;
Page/Page column 76 ;
反应条件
1: 2,3-dichloro-5-(trifluoromethyl)-pyridine With 4-(N,N-dimethlyamino)pyridine in anhydrous propionitrile 5 h; Heating / reflux; 2: sodium cyanide in water T=15°C; 5 h;
参考文献
US6699993 B1, ;
Page column 4 ;
反应条件
Burgess Reagent in tetrahydrofuran T=65°C; 1 h;
参考文献
WO2009/111337 A1, ;
Page/Page column 181 ;
WO 2009/111337 A1
反应条件
potassium cyanide; Aliquatreg; 336 in water T=30°C; 5 h;
参考文献
EP1199305 A1, ;
Example 2 ;
反应条件
in N-methyl-acetamide; diethyl ether
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=84°C; 10 h; Conversion of starting material;
参考文献
US6699993 B1, ;
Page column 3 ;
反应条件
4-(N,N-dimethlyamino)pyridine in anhydrous propionitrile T=98°C; 4 h; Conversion of starting material;
参考文献
US6699993 B1, ;
Page column 3 ;
反应条件
1: in tetrahydrofuran; toluene T=-5 - 20°C; 7 h; 2: With hydrogenchloride; water in tetrahydrofuran; toluene T=20°C; 3 h;
参考文献
Bayer CropScience S.A.
Patent: EP1548007 A1, 2005 ;
Location in patent: Page/Page column 44 ;
